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The calculator utilizes the incidence of trisomy chromosome conditions screened for by maternal age at 16 weeks gestational age.

For some conditions, such as 45, X and the microdeletion conditions, the incidence does not vary significantly with maternal age.

Neither the Foundation, NSGC, or any other individual, organization or other party involved in the preparation or publication of the Calculator or this website shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any use of or reliance upon the Calculator, the results or values generated by the Calculator or other information or materials included on this website.

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” For example, if the NPV is 99% in a given population, then approximately 99% of individuals who have a negative test result in that population would be expected to have an unaffected pregnancy.The rarer the condition in a given population, the lower the PPV when sensitivity and specificity remain unchanged.